#Dixon lab members are bolded.

2024

Park VS*, Pope LE*, Ingram J, Alchemy GA, Purkal J, Andino-Frydman EY, Jin S, Singh S, Chen A, Narayanan P, Kongpachith S, Phillips DC, Dixon SJ#, Popovic R#. Lipid composition differentiates ferroptosis sensitivity between in vitro and in vivo systems. BioRxiv. doi: https://doi.org/10.1101/2024.11.14.622381. *Equal contribution. #Co-corresponding author.

Fernandez E, Mai W, Song K, Bayley N, Kim J, Zhu H, Piosso M, Young P, Andrasz C, Cadet D, Liau L, Li G, Young W, Rodriguez F, Dixon SJ, Souers A, Li J, Graeber T, and Cloughesy T, Nathanson DA. Integrated molecular and functional characterization of the intrinsic apoptotic machinery identifies therapeutic vulnerabilities in malignant glioma. Nat Commun 15: 10089. [PubMed]

Murray MB#, Dixon SJ#. (2024). Ferroptosis regulation by Cap’n’collar family transcription factors. J Biol Chem 300: 107583. [Link] #Co-corresponding author.

Berndt C, Alborzinia H, Amen VS, Ayton S, Barayeu U, Bartelt A, Bayir H, Bebber CM, Birsoy K, Böttcher JP, Brabletz S, Brabletz T, Brown AR, Brüne B, Bulli G, Bruneau A, Chen Q, DeNicola GM, Dick TP, Distéfano A, Dixon SJ, Engler JB, Esser-von Bieren J, Fedorova M, Friedmann Angeli JP, Friese MA, Fuhrmann DC, García-Sáez AJ, Garbowicz K, Götz M, Gu W, Hammerich L, Hassannia B, Jiang X, Jeridi A, Kang YP, Kagan VE, Konrad DB, Kotschi S, Lei P, Le Tertre M, Lev S, Liang D, Linkermann A, Lohr C, Lorenz S, Luedde T, Methner A, Michalke B, Milton AV, Min J, Mishima E, Müller S, Motohashi H, Muckenthaler MU, Murakami S, Olzmann JA, Pagnussat G, Pan Z, Papagiannakopoulos T, Pedrera Puentes L, Pratt DA, Proneth B, Ramsauer L, Rodriguez R, Saito Y, Schmidt F, Schmitt C, Schulze A, Schwab A, Schwantes A, Soula M, Spitzlberger B, Stockwell BR, Thewes L, Thorn-Seshold O, Toyokuni S, Tonnus W, Trumpp A, Vandenabeele P, Vanden Berghe T, Venkataramani V, Vogel FCE, von Karstedt S, Wang F, Westermann F, Wientjens C, Wilhelm C, Wölk M, Wu K, Yang X, Yu F, Zou Y, Conrad M. (2024). Ferroptosis in health and disease. Redox Biol 75:103211. Online ahead of print.

Goncalves J, Dixon SJ. (2024). Waves of ferroptotic cell death sculpt embryonic tissue. Nature 631: 510-512. [Link]

Li Z, Lange M, Dixon SJ, Olzmann JA. (2024). Lipid quality control and ferroptosis: from concept to mechanism. Ann Rev Biochem 93: 499-528. [Link]

Berry CE, Kendig CB, An N, Fazilat AZ, Churukian AA, Griffin M, Pan PM, Longaker MT, Dixon SJ, Wan DC. (2024). Role of ferroptosis in radiation-induced soft tissue injury. Cell Death Discover 10: 313.

Dixon SJ#, Olzmann JA#. (2024). The cell biology of ferroptosis. Nat Rev Mol Cell Biol 25: 424-442. #Co-corresponding author.

Rodencal J, Kim N, He A, Li VL, Lange M, He J, Tarangelo A, Schafer ZT, Olzmann JA, Long JZ, Sage J, Dixon SJ. (2024). Sensitization of cancer cells to ferroptosis coincident with cell cycle arrest. Cell Chem Biol 31:234-248.e13. [PubMed] [previous BioRxiv]

2023

Dixon SJ#, Lee MJ#. (2023). Quick tips for interpreting cell death experiments. Nat Cell Biol 25: 1720-1723. #Corresponding authors. [Link]

Colville A, Liu J-Y, Rodriguez-Mateo C, Thomas S, Ishak HD, Zhou R, Klein JDD, Morgens DW, Goshayeshi A, Salvi JS, Yao D, Spees K, Dixon SJ, Liu C, Rhee J-W, Lai C, Wu JC, Bassik MC, Rando TA. (2023). Death-seq identifies regulators of cell death and senolytic therapies. Cell Metab 35: 1814-1829.e6. [PubMed]

Murray MB*#, Leak LB*, Lee WC*, Dixon SJ. (2023). Protocol for detection of ferroptosis in cultured cells. STAR Protoc 4: 102457. *Equal contribution. #Lead technical contact. [PubMed]

Pope LE, Dixon SJ. (2023). Regulation of ferroptosis by lipid metabolism. Trends Cell Biol. Online ahead of print. S0962-8924(23)00086-7. [PubMed]

Minami JK, Morrow D, Bayley NA, Fernandez EG, Salinas JJ, Tse C, Zhu H, Su B, Plawat R, Jones A, Sammarco A, Liau LM, Graeber TG, Williams KJ, Cloughesy TF, Dixon SJ#, Bensinger SJ#, Nathanson DA#. (2023). CDKN2A deletion remodels lipid metabolism to prime glioblastoma for ferroptosis. Cancer Cell 41: 1048-1060.e9. #Corresponding authors [PubMed]

Hendricks JM, Doubravsky CE, Wehri E, Li Z, Roberts MA, Deol KK, Lange M, Lasheras-Otero I, Momper JD, Dixon SJ, Bersuker K, Schaletzky J, Olzmann JA. (2023). Identification of structurally diverse FSP1 inhibitors that sensitize cancer cells to ferroptosis. Cell Chem Biol 30: 1090-1103.e7. [PubMed]

Papsdorf K, Miklas JW, Hosseini A, Cabruja M, Morrow CS, Savini M, Yu Y, Silva-García CG, Haseley NR, Murphy LM, Yao P, Launoit E, Dixon SJ, Snyder MP, Wang MC, Mair WB, Brunet A. (2023). Lipid droplets and peroxisomes are co-regulated to drive lifespan extension in response to mono-unsaturated fatty acids. Nat Cell Biol 25: 672-684. [PubMed]

Dixon SJ, Pratt DA. (2023). Ferroptosis: a flexible constellation of related biochemical mechanisms. Mol Cell 83: 1030-1042. [Link]

Bayir H, Dixon SJ, Tyurina Y, Kellum J, Kagan V. (2023). Ferroptotic mechanisms and therapeutic targeting of iron metabolism and lipid peroxidation in the kidney. Nat Rev Nephrol 19: 315-336. [Link]

Leak L, Dixon SJ. (2023). Surveying the landscape of emerging and understudied cell death mechanisms. BBA Mol Cell Res 1870: 119432. [Link]

2022

Rodencal J, Dixon SJ. (2022). A tale of two lipids: lipid unsaturation commands ferroptosis sensitivity. Proteomics Nov 18:e2100308. [Link]

Schmidt HB, Jafaar Z, Wulff BE, Rodencal JJ, Hong K, Aziz-Zanjani MO, Jackson PJ, Leonetti MD, Dixon SJ, Rohatgi R, Brandman O. (2022). Oxaliplatin disrupts nucleolar function through biophysical disintegration. Cell Rep 41: 111629. [Link] [previous BioRxiv]

Armenta DA*, Laqtom NN*, Alchemy G, Dong W, Morrow D, Poltorack C, Nathanson DA, Abu-Remaileh M#, Dixon SJ#. (2022). Ferroptosis inhibition by lysosome-dependent catabolism of extracellular protein. Cell Chem Biol 29: 1588-1600.e7. [Link]
*Equal contribution, #Corresponding authors

Perez MA, Clostio JA, Houston IR, Ruiz J, Magtanong J, Dixon SJ, Watts JL. (2022). Ether lipid deficiency disrupts lipid homeostasis leading to ferroptosis sensitivity. PLoS Genetics 18: e1010436. [Link]

Magtanong L, Mueller GD, Williams KJ, Billmann M, Chan K, Armenta DA, Pope LE, Moffat J, Boone C, Myers CL, Olzmann JA, Bensinger SJ, Dixon SJ. (2022). Context-dependent regulation of ferroptosis sensitivity. Cell Chem Biol 29: 1409-1418. [pdf] [Preview by Hyemin Lee and Boyi Gan in Cell Chem Biol]

Li L, Ferguson L, Deol KK, Roberts MA, Magtanong L, Hendricks JM, Mousa GA, Kilinc S, Schaefer K, Wells JA, Bassik MC, Goga A, Dixon SJ, Ingolia NT, Olzmann JA. (2022). Ribosome stalling during selenoprotein translation exposes a ferroptosis vulnerability in cancer. Nat Chem Biol 18: 751-761. [Link] [previous BioRxiv]

Kahlson MA, Dixon SJ. (2022). Copper-induced cell death. Science 375: 1231-1232. [Link]

Forcina GC, Pope L, Murray M, Dong W, Abu-Remaileh M, Bertozzi CR, Dixon SJ. (2022). Ferroptosis regulation by the NGLY1/NFE2L1 pathway. Proc Natl Acad Sci 119 (11) e2118646119. [Link] [previous BioRxiv version]

Rice MA, Kumar V, Tailor D, Garcia-Marques FJ, Hsu E-C, Liu S, Bermudez A, Kanchustambham V, Shankar V, Inde Z, Alabi BR, Muruganantham A, Shen M, Pandrala M, Nolley R, Aslan M, Ghoochani A, Agarwal A, Buckup M, Kumar M, Going CC, Peehl DM, Dixon SJ, Zare RN, Brooks JD, Pitteri SJ, Malhotra SV, Stoyanova T. (2022). SU086, an inhibitor of HSP90, impairs glycolysis and represents a treatment strategy for advanced prostate cancer. Cell Rep Med 3:100502. [PubMed]

Johnson FD, Ferrarone J, Liu A, Brandstädter C, Munuganti R, Farnsworth DA, Lu D, Luu J, Sihota T, Jansen S, Nagelberg A, Shi R, Forcina GC, Zhang X, Cheng GSW, Spencer Miko SE, de Rappard-Yuswack G, Sorensen PH, Dixon SJ, Guha U, Becker K, Djaballah H, Somwar R, Varmus H, Morin GB, Lockwood WW. (2022). Characterization of a small molecule inhibitor of disulfide reductases that induces oxidative stress and lethality in lung cancer cells. Cell Rep 38: 110343. [Link]

Tarangelo A, Rodencal J, Kim JT, Magtanong L, Long JZ, Dixon SJ. (2022). Nucleotide biosynthesis links glutathione metabolism to ferroptosis sensitivity. Life Sci Alliance 5:e202101157. [PubMed][previous BioRxiv version]

Ritho J, Dixon SJ. (2022). Excited to see you: new imaging approaches to detect ferrous iron. Cell Chem Biol 29: 3-4. [Link]

Rodencal J, Dixon SJ. (2022). Positive feedback amplifies ferroptosis. Nat Cell Biol 24: 4-5. [Link]

Poltorack CD, Dixon SJ. (2022). Understanding the role of cysteine in ferroptosis: progress & paradoxes. FEBS J 289: 374-385. [PubMed]

2021

Conlon M*, Poltorack CD*, Forcina GC*, Armenta DA, Mallais M, Perez M, Wells A, Kahanu A, Magtanong L, Watts J, Pratt D, Dixon SJ. (2021). A compendium of kinetic cell death modulatory profiles identifies ferroptosis regulators. Nat Chem Biol 17:665-674. [pdf][PubMed][previous BioRxiv version]
*equal contribution

Inde Z*, Rodencal J, Dixon SJ. (2021). Quantification of drug-induced fractional killing using high-throughput microscopy. STAR Protoc 2: 100300. [pdf][PubMed]
*Lead technical contact

2020

Chen Y-C, Oses-Prieto JA, Pope LE, Burlingame AL, Dixon SJ, Renslo AR. (2020). Reactivity-based probe of the iron(II)-dependent interactome identifies new cellular modulators of ferroptosis. JACS 142:19085-19093. [PubMed]

Riegman M, Sagie L, Galed C, Levin T, Steinberg N, Dixon SJ, Wiesner U, Bradbury MS, Niethammer P, Zaritsky A, Overholtzer M. (2020). Ferroptosis occurs through an osmotic mechanism and propagates independently of cell rupture. Nat Cell Biol 22:1042-1048. [PubMed]

Valente LJ, Tarangelo A, Li AM, Naciri M, Raj N, Boutelle AM, Li Y, Mello SS, Bieging-Rolett K, DeBerardinis RJ, Ye J, Dixon SJ, Attardi LD. (2020). p53 deficiency triggers dysregulation of diverse cellular processes in physiological oxygen. J Cell Biol 219:e201908212. [PubMed]

Perez M, Magtanong L, Dixon SJ, Watts JL. (2020). Dietary induction and modulation of ferroptosis in Caenorhabditis elegans. Dev Cell 54:1-8. [Link][previous BioRxiv version]

Inde Z, Forcina GC, Denton K, Dixon SJ. (2020). Kinetic heterogeneity of cancer cell fractional killing. Cell Rep 32:107845. [pdf] [previous BioRxiv version]

Armenta DA, Dixon SJ. (2020). Investigating nonapoptotic cell death using chemical biology approaches. Cell Chem Biol 27:376-386. [pdf][Link]

Dubreuil MM, Morgens DW, Okumoto K, Honsho M, Contrepois K, Lee-McMullen B, Traber GM, Sood RS, Dixon SJ, Snyder MP, Fujiki Y, Bassik MC. (2020). Systematic identification of regulators of oxidative stress reveals non-canonical roles for peroxisomal import and the pentose phosphate pathway. Cell Rep 30:1417-1433. [PubMed]

2019

Brown CW, Amante JJ, Chhoy P, Elaimy AL, Haibo L, Zhu LJ, Baer CE, Dixon SJ, Mercurio AM. (2019). Prominin2 drives ferroptosis resistance by stimulating multivesicular body/exosome-mediated iron export. Dev Cell 51: 575-586. [Link][PubMed]

Bersuker K, Hendricks J, Li Z, Magtanong L, Ford B, Tang PH, Roberts MA, Tong B, Maimone TJ, Zoncu R, Bassik MC, Nomura DK, Dixon SJ, Olzmann JA. (2019). The CoQ oxidoreductase FSP1 acts in parallel to GPX4 to inhibit ferroptosis. Nature 575:688-692. [Link][PubMed]

Ko P-J, Woodrow C, Dubreuil M, Martin B, Skouta R, Bassik M, Dixon SJ. (2019). A ZDHHC5-GOLGA7 protein acyltransferase complex promotes nonapoptotic cell death. Cell Chem Biol 26:1716-1724e9. [PubMed][pdf][Preview by Doug Green in Cell Chem Biol]

Tarangelo A, Dixon SJ. (2019). Lipid metabolism and ferroptosis. Ferroptosis in Health and Disease. Springer Press. pp 1-26. [Link]

Forcina GC, Dixon SJ. (2019). GPX4 at the Crossroads of Lipid Homeostasis and Ferroptosis. Proteomics Mar 19:e1800311. [Link]

Dixon SJ, Stockwell BR. (2019). The hallmarks of ferroptosis. Ann Rev Cancer Biol 3:35-54. [Link][pdf]

Magtanong L, Ko P-J, To M, Cao JY, Forcina GC, Tarangelo A, Ward CC, Cho KY, Patti GJ, Nomura DK, Olzmann JA, Dixon SJ. (2019). Exogenous monounsaturated fatty acids promote a ferroptosis-resistant cell state. Cell Chem Biol 26:1-13. [pdf][PubMed][Preview by Das in Cell Chem Biol]

Magtanong L, Dixon SJ. (2019). Ferroptosis and brain injury. Dev Neurosci 40:382-395. [Link]

Cao JY, Poddar A, Magtanong L, Lumb JH, Mileur TR, Reid MA, Dovey CM, Wang J, Locasale JW, Stone W, Cole SPC, Carette JE, Dixon SJ. (2019). A genome-wide haploid genetic screen identifies regulators of glutathione levels and ferroptosis sensitivity. Cell Rep 26:1544-1556. [Link][pdf]

2018

Ko P-J, Dixon SJ. (2018). Protein palmitoylation and cancer. EMBO Rep 19: e46666. [PubMed]

Dovey C, Diep J, Clarke BP, Hale AT, McNamara DE, Guo H, Brown Jr NW, Cao JY, Grace CR, Gough PJ, Bertin J, Dixon SJ, Fiedler D, Mocarski ES, Kaiser WJ, Moldoveanu T, York JD, Carette JE. (2018). MLKL requires the inositol phosphate code to execute necroptosis. Mol Cell 70: 936-948. [PubMed]

Tarangelo A, Dixon SJ. (2018). The p53-p21 pathway inhibits ferroptosis during metabolic stress. Oncotarget 9:24572-24573. [PubMed]

Inde Z, Dixon SJ. (2018). The impact of non-genetic heterogeneity on cancer cell death. Crit Rev Biochem Mol Biol 53: 99-114. [Link][PubMed]

Galluzzi L, Vitale I,...[many authors]...Dixon SJ,...[many authors]...Melino G, Kroemer G. (2018). Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death Differ 25: 486-541. [PubMed]

Tarangelo A, Magtanong L, Bieging-Rolett KT, Li Y, Ye J, Attardi L, Dixon SJ. (2018). p53 suppresses metabolic stress-induced ferroptosis in cancer cells. Cell Rep 22: 596-575. [pdf][PubMed][Faculty of 1000][Commentary by Kris Sarosiek in Sci Transl Med]

2017

Stockwell BR, Angeli JPF, Bayir H, Ashley I. Bush, Conrad M, Dixon SJ, Fulda S, Gascon S, Hatzios SK, Kagan V, Noel K, Jiang X, Linkermann A, Murphy ME, Overholtzer M, Oyagi A, Pagnussat G, Park J, Prives C, Ran Q, Rosenfeld CS, Salnikow K, Tang D, Torti F, Torti S, Toyokuni S, Woerpel KA, Zhang DD. (2017). Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease. Cell 171: 273-285. [pdf][PubMed]

Forcina GC, Conlon M, Wells A, Cao J-Y, Dixon SJ. (2017). Systematic quantification of cell death kinetics in mammalian cells. Cell Syst 4: 600-610. [pdf][PubMed][Commentary by Li & Yuan in Cell Chem Biol]

Conlon M, Dixon SJ. (2017). Ferroptosis-like cell death in plants. Mol Cel Oncol 4:e1302906. [PubMed]

Dixon SJ. (2017). Ferroptosis: bug or feature? Immunological Reviews 227: 150-157.  [pdf][PubMed]

Distéfano AM, Martin MV, Córdoba JP,  Bellido AM,D’Ippólito S,  Colman SL,  Soto D, Roldán JA,  Bartoli CG, Zabaleta EJ,  Fiol DF,  Stockwell BR,  Dixon SJ^, Pagnussat GC^. (2017). Heat stress induces ferroptosis-like cell death in plants. J Cell Biol 216:463-476. [Pubmed]
^Co-corresponding author

2016

Tarangelo A, Dixon SJ. (2016). An iron age for cancer therapy. Nat Nanotechnol 11:921-922. [Pubmed]

Magtanong L, Ko PJ, Dixon SJ. (2016). Emerging roles for lipids in non-apoptotic cell death. Cell Death Differ 23:1099-1109. [pdf][PubMed]

Cao J-Y, Dixon SJ. (2016). Mechanisms of ferroptosis. Cell Mol Life Sci 73:2195-2209. [pdf][PubMed]

Shimada K, Skouta R, Kaplan A, Yang WS, Hayano M, Dixon SJ, Brown LM, Valenzuela CA, Wolpaw AJ, Stockwell BR. (2016). Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis. Nat Chem Biol 12:497503. [PubMed]

2015

Dixon SJ^*, Winter GE*, Musavi LS, Lee E", Snijder B, Rebsamen M, Superti-Furga G^, Stockwell BR^. (2015).  Human haploid cell genetics reveals roles for lipid metabolism in non-apoptotic cell death. ACS Chem Biol 10:1604-1609. [PubMed]
^Co-corresponding author
*Equal contribution

Jacunski A, Dixon SJ, Tatonetti NP. (2015). Connectivity Homology Enables Inter-Species Network Models of Synthetic Lethality. PLoS Comp Biol. Oct 9;11(10):e1004506. [PubMed]

2014

Dixon SJ^, Stockwell BR^. (2014). The role of iron and reactive oxygen species in cell death. Nat Chem Biol 10: 9-17. [pdf] [PubMed]
^Co-corresponding author

Dixon SJ*, Patel DN*, Welsch M, Skouta R, Lee ED, Hayano M, Thomas AG, Gleason C, Tatonetti N, Slusher BS, Stockwell BR. (2014). Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis. eLife 20;3e02523. [PubMed]
*Equal contribution

Skouta R, Dixon SJ, Wang J, Dunn DE, Orman M, Shimada K, Rosenberg PA, Lo DC, Weinberg JM, Linkermann A, Stockwell BR. (2014). Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models. JACS 136: 4551-4556 [PubMed]

Some of Scott’s previous work before the opening the lab

Dixon SJ, Lemberg KM, Lampretch MR, Skouta R, Zaitsev EM, Gleason CM, Patel DN, Bauer AJ, Cantley AM, Yang WS, Morrison III B, Stockwell BR. (2012). Ferroptosis: A non-apoptotic form of iron-dependent cell death. Cell 149: 1060-1072. [pdf] [PubMed]

Dixon SJ*, Fedyshyn Y*, Koh JL*, Prasad TS, Chahwan C, Chua G, Toufighi K, Baryshnikova A, Hayles J, Hoe KL, Kim DU, Park HO, Myers CL, Pandey A, Durocher D, Andrews BJ, Boone C. (2008). Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes. Proc Natl Acad Sci 105: 16653-8. [pdf] [PubMed]
*Equal contribution

Dixon SJ*, Alexander M*, Chan KK, Roy PJ. (2008). Insulin-like signaling negatively regulates muscle arm extension through DAF-12 in Caenorhabditis elegans. Dev Biol 318: 153-61. [pdf] [PubMed]
*Equal contribution

Dixon SJ, Roy PJ. (2005). Muscle arm development in Caenorhabditis elegans. Development 132: 3079-3092. [pdf] [PubMed]

^Co-corresponding author
*Equal contribution