Huge advance from Tony Pawson's lab in our understanding of signaling dynamics downstream of receptor tyrosine kinase activation. They use scheduled multiple reaction monitoring to define how the composition of a signaling complex nucleated by the Shc1 adapter protein changes over time, directing different outputs downstream of EGF receptor activation. Makes me nostalgic: my first graduate project concerned a related protein, FRS3. Also was very fortunate to have Tony as one of my thesis committee members back in Toronto.